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Single or multiple episodes of definite persistent aura

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SYMPTOMS | PATHOMECHANISMS | HISTORY

Symptoms

Transitory aura symptoms

Persistent aura symptoms

Internet survey

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Def. pers. aura

Worsening factor...

Improving factor...

VS and spiritual...

Persistent aura and spirituality

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Psychological experience

Author: Klaus Podoll, Markus Dahlem, Sofia Greene	27. February 2007
Edited by: Klaus Podoll, Markus Dahlem, Sofia Greene

Single or multiple episodes of definite persistent aura

With each migraine some of the photopsias began to persist and accumulate

"A 32-year-old woman had a long personal history of migraine headaches accompanied by typical auras of photopsias... In 1990, with each migraine some of the photopsias began to persist and accumulate, ecentually encompassing her entire visual field all of the time."

(Liu et al., 1995, case 1)

Of the 60 subjects with suspected diagnosis of definite persistent aura without infarction, 24 (40,0 %) reported a single episode (subjects #8, #14, #20, #30, #80, #136, #142, #152, #153, #156, #159, #167, #168, #169, #180, #182, #233, #254, #257, #258, #264, #265, #283, #300) and 36 (60,0 %) multiple episodes of persistent aura (subjects #1, #23, #42, #45, #52, #73, #75, #85, #86, #104, #120, #138, #141, #145, #147, #157, #162, #171, #172, #175, #179, #185, #189, #200, #217, #228, #230, #234, #235, #240, #273, #276, #277, #284, #296, #301), described by sufferers as "episodes", "flares", "rounds of symptoms" or "bouts of aura", respectively.

Multiple episodes of persistent aura without infarction

"Hello, I am new to this forum, but thought I'd see if anyone could help. I am a 34 year old female & have had typical migraines with aura, head pain & nausea since I was 8. In 1994 I had a migraine in which the aura (flashing lights & dark spots) never went away. An MRI showed nothing was wrong. At the time I was told it was probably some permanent damage to my optic nerve. I was able to adjust & it didn't bother me too much. Subsequent migraines would cause an aura that was more obscuring than the day to day visual disturbance.

Three weeks ago I had another migraine in which this more obscuring aura has not gone away. This has caused great discomfort as I now feel dizzy & nauseous often.

My neurologist has ordered a new MRI and an EEG. He also prescribed Depakote which a 1997 study had shown to offer some improvement.

Does anyone have any current information on this condition or know of anyone doing research or clinical trials? I am told this is extremely rare, but that is little comfort to someone who has it."

(Seeing Spots, ACHENet forums – Headache Talk – Ask the Expert – Persistant aura from migraine, February 23, 2004)

An episode of persistent aura was defined by (1) the onset of at least one persistent aura symptom (duration > 1 week) following a period > 2 weeks with a stable or improving neurological status and/or (2) a clinically significant worsening of at least one pre-existing persistent aura symptom (duration > 1 week) following a period > 2 weeks with a stable or improving neurological status. If the onset of at least one persistent aura symptom and/or the clinically significant worsening of at least one pre-existing persistent aura symptoms occurs within an interval of 2 weeks, these events are coded as belonging to a single episode of persistent aura.

The mean number of episodes was 2,8 (range 1 - 29) for the 60 subjects with definite persistent aura.

winklemouse [subject #471], Single string floater brought on by 2nd episode of persistent aura (1980), 2007. "My view pre-2007... From high school (ca. 1979) until February 2007, I'd always had just one small string floater." © 2007 winklemouse

winklemouse [subject #471], Significant worsening of string floaters brought on by 5th episode of persistent aura (February 2007), 2007. "Around February 2007, there were about 5 new ones I'd never seen before." © 2007 winklemouse

winklemouse [subject #471], Significant worsening of string floaters brought on by 6th episode of persistent aura (ca. July 2007), 2007. "A large portion of the persistent... strings appeared over a months time last summer." © 2007 winklemouse

winklemouse [subject #471], Significant worsening or string floaters brought on by the 7th episode of persistent aura (ca. October 2007), 2007. "The rest [of the persistent strings] showed themselves in October 2007... View view now... through the fish bowl..." © 2007 winklemouse

References

Liu GT, Schatz NJ, Galetta SL, Volpe NJ, Skobieranda F, Kosmorsky GS. Persistent positive visual phenomena in migraine. Neurology 1995; 45: 664-668.

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Pre-publication research on migraine with aura

NEW BOOK: Klaus Podoll & Derek Robinson, Migraine Art - The Migraine Experience from Within