LSD - Flesh of Devil, 1967 (see here, here, here and here)
According to a review from Halpern and Pope (2003), "'Flashbacks' following use of hallucinogenic drugs have been reported for decades; they are recognized in DSM-IV as 'Hallucinogen Persisting Perception Disorder (Flashbacks)', or HPPD. We located and analyzed 20 quantitative studies between 1955 and 2001 examining this phenomenon. However, many of these studies were performed before operational criteria for HPPD were published in DSM-III-R, so they are difficult to interpret in the light of current diagnostic criteria. Overall, current knowledge of HPPD remains very limited. In particular (1) the term 'flashbacks' is defined in so many ways that it is essentially valueless; (2) most studies provide too little information to judge how many cases could meet DSM-IV criteria for HPPD; and consequently (3) information about risk factors for HPPD, possible etiologic mechanisms, and potential treatment modalities must be interpreted with great caution. At present, HPPD appears to be a genuine but uncommon disorder, sometimes persisting for months or years after hallucinogen use and causing substantial morbidity. It is reported most commonly after illicit LSD use, but less commonly with LSD administered in research or treatment settings, or with use of other types of hallucinogens. There are case reports, but no randomized controlled trials, of successful treatment with neuroleptics, anticonvulsants, benzodiazepines, and clonidine. Although it may be difficult to collect large samples of HPPD cases, further studies are critically needed to augment the meagre data presently available regarding the prevalence, etiology, and treatment of HPPD."
Henry David Abraham, MD. © 2006 Henry David Abraham
Dr. Henry David Abraham described the "Visual phenomenology of the LSD flashback" in 1983 (see Abraham, 1983, and the HPPD summary at Dr. Abraham's homepage). The formerly used term LSD flashback should be replaced by the term HPPD, because, as Abraham et al. (1996) remarked, "flashback appears to be a misnomer, as patients described cases of continuous, rather than paroxysmal, visual disturbances from LSD" (p. 292).
Illustration of aeropsia by an HPPD patient of Dr. Henry David Abraham. © 2006 Henry David Abraham
The above drawing from an HPPD patient of Dr. Abraham illustrates visual hallucinations described by the sufferer as countless "shimmering, flowing" dots floating in the air, "a pervasive part of my entire visual field". This type of hallucination, in which the patient literally "sees the air", was called "aeropsia" by Abraham (1983).
DOHP, HPPD visuals, 2007. © 2007 DOHP (see here)
Another HPPD sufferer, DOHP, described his visuals thus: "My most interesting OEV I get is from meditating, I made a very, very rough gif of what I see. To describe it further, it is like tiny blue balls of light/energy with a light blue/yellow trail behind it moving in different directions; when they reach the destination they dissapear and restart from where they were, this cycle takes around 1 second or less."
(DOHP, Bluelight - Focus Forums - Psychedelic Drugs - Describe your visuals..., June 5, 2007)
He added: "And it resembles almost the exact way brain signals/neurons interact, which makes me wounder if I am seeing the brain working. Does anybody else have the same visuals as this? As I am fascinated at how much it resembles brain neurons."
(DOHP, Bluelight - Focus Forums - Psychedelic Drugs - Describe your visuals..., June 5, 2007)
Jespar, Tracers, 2006 (see here)
Abraham HD. Visual phenomenology of the LSD flashback. Arch Gen Psychiatry 1983; 40: 884-889. [PDF]
Abraham HD, Aldridge AM, Gogia P. The psychopharmacology of hallucinogens. Neuropsychopharmacology 1996; 14: 285-298, 1996. [PDF]
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-IV. 4th ed. American Psychiatric Association, Washington, DC 1994.
Halpern JH, Pope HG Jr. Hallucinogen persisting perception disorder: what do we know after 50 years? Drug Alcohol Depend 2003; 69: 109-119. [PDF]
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