Beginning with the pioneering study of Lashley from 1941, notions about functional models have unfolded in a number of scientific papers covering a period up to the present.
Lashley's scotomas can be mapped from the visual field (left) onto the cortical surface (right). The kidney shape is transformed to a wave front with constant width (Dahlem, 2000). © 2000 Markus Dahlem
A first attempt to connect migraine with a cerebral propagation phenomenon was already made in 1941 by Lashley. He layed the ground for many follow up theoretical research. [more]
Norbert Wiener and Arturo Rosenblueth gave the starting signal for theoretical research in this field. [more]
Richards looked for details in visual aura pattern to deduce functional cortical organisation. [more]
Schwartz argued on the basis of detailed cortical circuitry to explain visual aura pattern. [more]
Quantitative observations on the shape and position of visual migraine aura were provided by this renowned researcher. [more]
The neurocomputational perspective was further developed by a detailed neural network model. [more]
Dahlem developes neural network models of the visual cortex to test whether the aura can be understood in terms of functional cortical organization and to reveal the underlying cause. [more]
Markus A. Dahlem, Modellierung gesichtsfeldbezogener Phänomene bei der Migräne Aura auf der Grundlage von Erregungswellen in der primären Sehrinde. Diss. Otto-von-Guericke University, Magdeburg 2000.
Dahlem MA, Engelmann R, Lowel S, Muller SC. Does the migraine aura reflect cortical organization? Eur J Neurosci 2000; 12: 767-770.
Grusser OJ. Migraine phosphenes and the retino-cortical magnification factor. Vision Res 1995; 35: 1125-1134.
Lashley K. Patterns of cerebral integration indicated by scotomas of migraine. Arch Neurol Psychiatry 1941; 46: 331-339.
Reggia JA, Montgomery D. A computational model of visual hallucinations in migraine. Comput Biol Med 1996; 26: 133-141.
Richards W. The fortification illusions of migraines. Sci Am 1971; 224: 88-96.
Schwartz EL. A quantitative model of the functional architecture of human striate cortex with application to visual illusion and cortical texture analysis. Biol Cybern 1980; 37: 63-76.
Wiener N, Rosenbluth A. The mathematical formulation of the problem of conduction of impulses in a network of connected excitable elements, specifically in cardiac muscle. Arch Inst Cardiol Mex 1946; 16: 205-265.
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